Toxicity

Toxicity Study I (Use of Mercury in Tibetan Medicine)
Toxicology study on use of Tsothel (detoxified mercury) in Tibetan medicine for 11 patients was done in the year 2003. It was an open, retrospective controlled pilot study, constituting an initial feasibility stage of a larger, future prospective study in collaboration with Natural Medicine Research Unit, Israel; Delek Hospital, Dharamsala, India; Dept. of Chemistry, University of Liverpool, Liverpool, UK. The study concluded that pre-longed use of detoxified mercury (Tsothel) doesn’t show any sign of toxicity as speculated by western bio-medicine.
The current study, although  performed on only a small cohort of patients tend to support the hypothesis that a prolonged intake of the purified form of mercury, known as Tsothel in Tibetan Medicine is relatively non-toxic. These initial results are of particular interest in view of the growing popularity of Tibetan Medicine in the west; however there is no doubt that further research needs to be performed. The detail report of the study was published in Human & Experimental Toxicology Medical Journal with reference to Human & Experimental Toxicology (2006)25:405-412 and in sMen-rTsis Journal vol. IV, 2007

Cell Line Study 
The purpose of this study was to explore the possible stimulating effects of the Tibetan Medicine called Pokar 10 in two cell types that have been stressed in an impoverished medium over 5 days. This study was carried out in May, 2004 in collaboration with Tissue Culture laboratory at Portland Community College, Portland, Oregon, USA. Both cell types were fibroblasts, fast growing connective tissue cells secreting an extra cellular matrix rich in collagen and other macromolecules. The Tibetan Medicine Pokar 10 is often given for the treatment of joint inflammation/ pain and skin diseases.
The cell submitted to concentrations of Tibetan Medicine were noticed to be growing "extensions" to their cytoplasm material, appearing to reach specifically for the Tibetan compound, grabbing and engulfing bit of it. This movement in the direction of the Tibetan Medicine can be referred to as a positive chemotropic response. Further testing would be required to continue documenting the earlier responses of the fibroblast cells, and also to attempt to understand and explain the physiological mechanisms by which the Tibetan Medicine was able to beneficially affect the culture cell line. The detail report has been published in sMan -rTsis Journal of Men-Tsee-Khang (English), Vol. IV, Issue 1, August, 2007